홈페이지
학력
Mar 1998 - Aug 2002
B.S. in Biology Education
Department of Biology Education,
Seoul National University, Seoul, Korea
Sep 2002 - Aug 2008
Ph.D. in Biological Sciences (Molecular Immunology)
School of Biological Sciences,
Seoul National University, Seoul, Korea (Advisor: Dr. Rho H. Seong)
Thesis Title: Studies on the transcriptional control of SRG3, a core
subunit of the SWI/SNF complea, and its tumor suppressive
roles via p53-mediated p21WAF1/CIP1 regulation
B.S. in Biology Education
Department of Biology Education,
Seoul National University, Seoul, Korea
Sep 2002 - Aug 2008
Ph.D. in Biological Sciences (Molecular Immunology)
School of Biological Sciences,
Seoul National University, Seoul, Korea (Advisor: Dr. Rho H. Seong)
Thesis Title: Studies on the transcriptional control of SRG3, a core
subunit of the SWI/SNF complea, and its tumor suppressive
roles via p53-mediated p21WAF1/CIP1 regulation
경력
Sep 2008 - Apr 2009
Post-doctoral fellow (Laboratory of Dr. Rho Hyun Seong)
Laboratory of Molecular Immunology,Laboratory of Molecular Immunology,
Seoul National University, Seoul, Korea
Apr 2009 - Mar 2010
Post-doctoral Fellow (Laboratory of Dr. Anjana Rao)
Department of Pathology, Harvard Medical School,
Immune Disease Institute and Program in Cellular and Molecular
Medicine at Children’s Hospital Boston, Boston, MA
Mar 2010 - Jun 2015
Post-doctoral fellow (Laboratory of Dr. Anjana Rao)
Division of Signaling and Gene e-x-p-r-e-s-s-i-o-n,
La Jolla Institute for Allergy and Immunology, La Jolla, CA
Aug 2015 - Jun 2016
Research fellow (Laboratory of Dr. Kyungjae Myung)
Center for Genomic Integrity,
Institute for Basic Science, UNIST, Ulsan, Korea
Post-doctoral fellow (Laboratory of Dr. Rho Hyun Seong)
Laboratory of Molecular Immunology,Laboratory of Molecular Immunology,
Seoul National University, Seoul, Korea
Apr 2009 - Mar 2010
Post-doctoral Fellow (Laboratory of Dr. Anjana Rao)
Department of Pathology, Harvard Medical School,
Immune Disease Institute and Program in Cellular and Molecular
Medicine at Children’s Hospital Boston, Boston, MA
Mar 2010 - Jun 2015
Post-doctoral fellow (Laboratory of Dr. Anjana Rao)
Division of Signaling and Gene e-x-p-r-e-s-s-i-o-n,
La Jolla Institute for Allergy and Immunology, La Jolla, CA
Aug 2015 - Jun 2016
Research fellow (Laboratory of Dr. Kyungjae Myung)
Center for Genomic Integrity,
Institute for Basic Science, UNIST, Ulsan, Korea
최근 발표 논문
1. Jungeun An, Edahi Gonzalez-Avalos, Ashu Chawla, Mira Jeong, Isaac F. Lopez-Moyado, Wei Li, Margaret A. Goodell, Lukas Chavez#, Myunggon Ko# & Anjana Rao#. (2015) Acute deletion of TET functionresults in aggressive myeloid cancer in mice. Nat. Commun. 6:10071. doi: 10.1038/ncomms10071. (IF: 11.470)
2. Myunggon Ko, Jungeun An and Anjana Rao. (2015) DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Curr. Opinion in Cell Biol. 37: 91-101. (IF: 8.467)
3. Jae-A Han, Jungeun An, and Myunggon Ko. (2015) Functions of TET proteins in hematopoietic transformation. Mol. Cells 38(11): 925-935. (IF: 2.090)
4. Myunggon Ko*, Jungeun An*, William A. Pastor, Sergei B. Koralov, Klaus Rajewsky and Anjana Rao. (2015) TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunological Reviews 263: 6-21(*equally contributed) (IF: 10.120)
5. Myunggon Ko*, Jungeun An*, Hozefa S. Bandukwala, Lukas Chavez, Tarmo Aijo, William A. Pastor, Matthew F. Segal, Huiming Li, Kian Peng Koh, Harri Lahdesmaki, Patrick G. Hogan, L. Aravind, Anjana Rao. (2013). Modulation of TET2 e-x-p-r-e-s-s-i-o-n and 5-methylcytosine oxidation by the CXXC domain protein IDAX, Nature 497: 122-126. (*equally contributed) (IF: 41.456)
6. Myunggon Ko*, Hozefa S. Bandukwala*, Jungeun An, Edward D. Lamperti, Elizabeth C. Thompson, Ryan Hastie, Angeliki Tsangaratou, Klaus Rajewsky, Sergei B. Koralov, and Anjana Rao. (2011). Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice, Proc. Natl. Acad. Sci. USA 108: 14566-14571. (IF: 9.674)
7. Myunggon Ko*, Yun Huang*, Anna M. Janowska, Utz J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, Rebecca Ganetzky, X. Shirley Liu, L. Aravind, Suneet Agarwal, Jaslow P. Maciejewski & Anjana Rao. (2010). Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2, Nature 468: 839-843. (IF: 41.456)
8. Jeongeun Ahn*, Myunggon Ko*, Changjin Lee, Jieun Kim, Hana Yoon, and Rho H. Seong (2010). Srg3 is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 e-x-p-r-e-s-s-i-o-n. Oncogene 30: 445-456. (*equally contributed). (IF: 8.459)
9. Jeongeun Ahn*, Myunggon Ko*, Kyuyoung Lee, Jaehak Oh, Sung H. Jeon and Rho H. Seong. (2005). e-x-p-r-e-s-s-i-o-n of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factors. Biochem. Biophysic. Res. Comm. 338: 1435-1446. (*equally contributed). (IF: 2.297)
10. Myunggon Ko, Jiho Jang, Jeongeun Ahn, Kyuyoung Lee, Heekyoung Chung, Sung H. Jeon, and Rho H. Seong. (2004) T cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 e-x-p-r-e-s-s-i-o-n via Ras activation. J. Biol. Chem. 279: 21903-21915. (IF: 4.573)
11. Myunggon Ko, Jeongeun Ahn, Changjin Lee, Heekyoung Chung, Sung H. Jeon, Hee-Y. Chung, and Rho H. Seong. (2004). E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 e-x-p-r-e-s-s-i-o-n. J. Biol. Chem. 279: 21916-21923. (IF: 4.573)
2. Myunggon Ko, Jungeun An and Anjana Rao. (2015) DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Curr. Opinion in Cell Biol. 37: 91-101. (IF: 8.467)
3. Jae-A Han, Jungeun An, and Myunggon Ko. (2015) Functions of TET proteins in hematopoietic transformation. Mol. Cells 38(11): 925-935. (IF: 2.090)
4. Myunggon Ko*, Jungeun An*, William A. Pastor, Sergei B. Koralov, Klaus Rajewsky and Anjana Rao. (2015) TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunological Reviews 263: 6-21(*equally contributed) (IF: 10.120)
5. Myunggon Ko*, Jungeun An*, Hozefa S. Bandukwala, Lukas Chavez, Tarmo Aijo, William A. Pastor, Matthew F. Segal, Huiming Li, Kian Peng Koh, Harri Lahdesmaki, Patrick G. Hogan, L. Aravind, Anjana Rao. (2013). Modulation of TET2 e-x-p-r-e-s-s-i-o-n and 5-methylcytosine oxidation by the CXXC domain protein IDAX, Nature 497: 122-126. (*equally contributed) (IF: 41.456)
6. Myunggon Ko*, Hozefa S. Bandukwala*, Jungeun An, Edward D. Lamperti, Elizabeth C. Thompson, Ryan Hastie, Angeliki Tsangaratou, Klaus Rajewsky, Sergei B. Koralov, and Anjana Rao. (2011). Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice, Proc. Natl. Acad. Sci. USA 108: 14566-14571. (IF: 9.674)
7. Myunggon Ko*, Yun Huang*, Anna M. Janowska, Utz J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, Rebecca Ganetzky, X. Shirley Liu, L. Aravind, Suneet Agarwal, Jaslow P. Maciejewski & Anjana Rao. (2010). Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2, Nature 468: 839-843. (IF: 41.456)
8. Jeongeun Ahn*, Myunggon Ko*, Changjin Lee, Jieun Kim, Hana Yoon, and Rho H. Seong (2010). Srg3 is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 e-x-p-r-e-s-s-i-o-n. Oncogene 30: 445-456. (*equally contributed). (IF: 8.459)
9. Jeongeun Ahn*, Myunggon Ko*, Kyuyoung Lee, Jaehak Oh, Sung H. Jeon and Rho H. Seong. (2005). e-x-p-r-e-s-s-i-o-n of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factors. Biochem. Biophysic. Res. Comm. 338: 1435-1446. (*equally contributed). (IF: 2.297)
10. Myunggon Ko, Jiho Jang, Jeongeun Ahn, Kyuyoung Lee, Heekyoung Chung, Sung H. Jeon, and Rho H. Seong. (2004) T cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 e-x-p-r-e-s-s-i-o-n via Ras activation. J. Biol. Chem. 279: 21903-21915. (IF: 4.573)
11. Myunggon Ko, Jeongeun Ahn, Changjin Lee, Heekyoung Chung, Sung H. Jeon, Hee-Y. Chung, and Rho H. Seong. (2004). E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 e-x-p-r-e-s-s-i-o-n. J. Biol. Chem. 279: 21916-21923. (IF: 4.573)