이상배 사진
이상배
전공
생화학 및 분자세포생물학
전화번호
063-270-4856
이메일
leesb@jbnu.ac.kr
실험실
생화학실험실
연구실
자연과학대학 2호관 313호

홈페이지


학력

2006.09 ~ 2011.08
Ph.D., Sungkyunkwan University School of Medicine, Korea (Dissertation advisor: Jee-Yin Ahn, Ph.D.)

2004.03 ~ 2006.02
M.S., Catholic university School of Medicine, Korea

1999.03 ~ 2004.02
B.S., College of Advanced Science, Dankook university, Korea

경력

2019.09 ~ present
Division of Life Sciences, Jeonbuk National University, Republic of Korea Assistant professor

2017.11 ~ 2019.08 Institute for Cancer Genetics, Columbia University, New York, NY Associate Research Scientist

2013.01 ~ 2017.10
Institute for Cancer Genetics, Columbia University, New York, NY Postdoctoral Research Scientist (Mentor: Dr. Antonio Iavarone and Dr. Anna Lasorella)

2011.08 ~ 2012.12
Samsung Biomedical Research Institute / Sungkyunkwan University School of Medicine, Korea Senior Researcher / PostDoc fellow (Mentor: Dr. Jee-Yin Ahn)

최근 발표 논문

19) Lee S.B., Kim H.K., Oh H.K., Hong Y.K., and Joe Y.A. (2006) Mutation of Angiogenesis Inhibitor TK1-2 to Avoid Antigenicity In Vivo. J Appl Pharm. 14, 30-35. (Biomol Ther. 14, 30-35). IF(2018): 3.089

18) Xuan Nguyen T.L., Choi J.W., Lee S.B., Ye K., Woo S.D., Lee K.H., and Ahn J.Y. (2006) Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells. Biochem Biophys Res Commun. 349(2), 789-798. IF(2018): 2.705, PMID: 16956580; DOI: 10.1016/j.bbrc.2006.08.120

17) Lee S.B., Oh H.K., Kim H.K., and Joe Y.A. (2006) e-x-p-r-e-s-s-i-o-n of the non-glycosylated kringle domain of tissue type plasminogen activator in Pichia and its anti-endothelial cell activity. Protein Expr Purif. 50(1), 1-8. IF(2018): 1.291, PMID: 16854593; DOI: 10.1016/j.pep.2006.06.002

16) Choi J.W.*, Lee S.B.*, Kim C.K., Lee K.H., Cho S.W., and Ahn J.Y. (2008) Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability. FEBS Lett. 582(7), 1073-1080. (* These authors contributed equally to this work). IF(2018): 2.675, PMID: 18319061; DOI: 10.1016/j.febslet.2008.02.059

15) Kim H.K., Oh D.S., Lee S.B., Ha J.M., and Joe Y.A. (2008) Antimigratory effect of TK1-2 is mediated in part by interfering with integrin alpha2beta1. Mol Cancer Ther. 7(7), 2133-2141. IF(2018): 4.856, PMID: 18645023; DOI: 10.1158/1535-7163.MCT-07-2405

14) Lee S.B., Xuan Nguyen T.L., Choi J.W., Lee K.H., Cho S.W., Liu Z., Ye K., Bae S.S., Ahn J.Y. (2008) Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci USA. 105(43), 16584-16589. IF(2018): 9.580, PMID: 18931307; PMCID: PMC2569968; DOI: 10.1073/pnas.0807668105

13) Choi J.W., Lee S.B., Ahn J.Y., Lee K.H. (2008) Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function. BMB Rep. 41(12), 840-845. IF(2018): 2.966, PMID: 19123973; DOI: 10.5483/bmbrep.2008.41.12.840

12) Nguyen N., Lee S.B., Lee Y.S., Lee K.H., Ahn J.Y. (2009) Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res. 34(5), 942-951. IF(2018): 2.782, PMID: 18846424; DOI: 10.1007/s11064-008-9848-9

11) Lee S.B., Kwon I.S., Park J., Lee K.H., Ahn Y., Lee C., Kim J., Choi S.Y., Cho S.W., Ahn J.Y. (2010) Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem. 285(38), 29457-29468. IF(2018): 4.106, PMID: 20605787; PMCID: PMC2937978; DOI: 10.1074/jbc.M110.131367

10) Kim C.K.*, Nguyen T.L.*, Lee S.B.*, Park S.B., Lee K.H., Cho S.W., Ahn J.Y. (2011) Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells. Exp Cell Res. 317(7), 966-975. (* These authors contributed equally to this work). IF(2018): 3.329, PMID: 21182834; DOI: 10.1016/j.yexcr.2010.12.013

9) Kim C.K., Lee S.B., Nguyen T.L., Lee K.H., Um S.H., Kim J., Ahn J.Y. (2012) Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. Exp Cell Res. 318(2), 136-143. IF(2018): 3.329, PMID: 21930127; DOI: 10.1016/j.yexcr.2011.08.013

8) Park J.H.*, Lee S.B.*, Lee K.H., Ahn J.Y. (2012) Nuclear Akt promotes neurite outgrowth in the early stage of neuritogenesis. BMB Rep. 45(9), 521-525. (* These authors contributed equally to this work). IF(2018): 2.966, PMID: 23010173; DOI: 10.5483/bmbrep.2012.45.9.114

7) Lee S.B., Kim C.K., Lee K.H., Ahn J.Y. (2012) S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1/GAPDH death cascade. J Cell Biol. 199(1), 65-76. IF(2018): 8.891, PMID: 23027902; PMCID: PMC3461512; DOI: 10.1083/jcb.201205015

6) Ko H.R., Kim C.K., Lee S.B., Song J., Lee K.H., Kim K.K., Park K.W., Cho S.W., Ahn J.Y. (2014) P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. Cell Death Dis. 5, e1131. IF(2018): 5.959, PMID: 24651434; PMCID: PMC3973206; DOI: 10.1038/cddis.2014.79

5) Lee S.B., Frattini V., Bansal M., Castano A.M., Sherman D., Hutchinson K., Bruce J.N., Califano A., Liu G., Cardozo T., Iavarone A., Lasorella A. (2016) An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 529(7585), 172-177 (Article). IF(2018): 43.070, PMID: 26735018; PMCID: PMC5384647; DOI: 10.1038/nature16475

4) Park J.H., Kim C.K., Lee S.B., Lee K.H., Cho S.W., Ahn J.Y. (2016) Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Sci Rep. 6(1), 21857. IF(2018): 4.011, PMID: 26899247; PMCID: PMC4761890; DOI: 10.1038/srep21857

3) Frattini V.*, Pagnotta S.M*., Tala, Fan J.J., Russo M.V., Lee S.B., Garofano L., Zhang J. Shi P., Lewis G., Sanson H., Frederick V., Castano A.M., Cerulo L., Rolland D.C.M., Mall R., Mokhtari K., Elenitoba-Johnson K.S.J., Sanson M., Huang X., Ceccarelli M., Lasorella A., Iavarone A. (2018) A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 553(7687), 222-227. (* These authors contributed equally to this work).  Toker A and Liu H: F1000Prime Recommendation In F1000Prime, 01 Feb 2018; 10.3410/f.732450582.793541872 IF(2018): 43.070, PMID: 29323298; PMCID: PMC5771419; DOI: 10.1038/nature25171

2) Ko H.R., Jin E.J., Lee S.B., Kim C.K., Cho S.W., Yun T., Park K.W., Ahn J.Y. (2019) SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development. J Biol Chem. [Epub ahead of print]. IF(2018): 4.106, PMID: 31471318; DOI: 10.1074/jbc.RA119.009618

1) Wojnarowicz P.M., Lima E. Silva R., Ohnaka M., Lee S.B., Chin Y., Kulukian A., Chang S.H., Desai B., Garcia Escolano M., Shah R., Garcia-Cao M., Xu S., Kadam R., Goldgur Y., Miller M.A., Ouerfelli O., Yang G., Arakawa T., Albanese S.K., Garland W.A., Stoller G., Chaudhary J., Norton L., Soni R.K., Philip J., Hendrickson R.C., Iavarone A., Dannenberg A.J., Chodera J.D., Pavletich N., Lasorella A., Campochiaro P.A., Benezra R. (2019) A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 29(1), 62-75.e7 IF(2018): 7.815, PMID: 31577956; DOI: 10.1016/j.celrep.2019.08.073

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